5-HT3受体拮抗剂所致便秘中医诊治思路与方法

TCM diagnosis thoughts and methods on constipation caused by 5-HT3 receptor antagonist

目的:研究中医治疗5-HT3受体拮抗剂所致便秘的思路与方法。方法:通过对肿瘤化疗病人因应用5-HT3受体拮抗剂而出现的不良反应-便秘的症状、舌象、脉象进行辨证分析,得出辨证结论,分析治疗方法。结果:5-HT3受体拮抗剂所致便秘中医辨证为阴虚燥结,治以滋阴通腑泻热,方药选用增液承气汤。结论:增液承气汤是治疗5-HT3受体拮抗剂所致便秘的有效方剂,而且能提高5-HT3受体拮抗剂的止吐效果。

Objective： To investigate the TCM therapy thoughts and methods of constipation caused by 5-HT3 receptor antagonist. Methods： The adverse reactions caused by application of 5＋HT3 receptor antagonist, including constipation, tongue manifestation and pulse manifestation were analyzed based on different symptoms andsigns. Results： The constipation caused by 5-HT3 receptor antagonist was diagnosed as yin astheflia and fluid-consuming constipation. Zengye Chengqi decoction was used to Ziyin Tongfu and Xieye. ConcluSion： Zengye Chengqi decoction was effective on treating constipation caused by 5-HT3 receptor antagonist, and it could also improve the vomit-stopping effect of 5-HT3 receptor antagonist.