参麦注射液在感染性休克治疗中的应用效果观察

Therapeutic effect of Shenmai injection in the treatment of septic shock

目的观察参麦注射液在感染性休克治疗中的作用。方法将72例临床确诊的感染性休克患者随机分为对照组(n=35)和治疗组(n=37),两组患者均按照指南给予抗感染、抗休克常规治疗。治疗组加用参麦注射液,分别观察两组患者治疗前和治疗后(1h、3h、6h、12h)的心率、平均动脉压、尿量、中心静脉压的变化,并比较两组治疗前后6h血乳酸水平、白细胞计数、补液量以及血管活性药物的用量。结果两组患者在治疗后均出现心率减慢、平均动脉压升高,且治疗组变化较对照组好,差异具有统计学意义(P<0.05)。治疗6h后治疗组血乳酸水平、补液量以及血管活性药物的用量明显低于对照组(P<0.05)。结论参麦注射液可升高感染性休克患者的平均动脉压、减慢心率,降低血乳酸水平,改善组织灌注,并减少补液量及血管活性药物的用量。

Objective To observe the therapeutic effect of Shenmai injection in the treatment of septic shock. Methods Seventy-two patients clinically diagnosed with septic shock were randomly divided into the control group （n=35） and the treatment group （n=37）. Patients in both the two groups were given conventional treatment according to the International Guidelines for Management of Severe Sepsis and Septic Shock 2008. The treatment group was treated with Shenmai injection additionally. The heart rate, mean arterial pressure, urine output, central venous pressure before and after treatment （1 h, 3 h, 6 h, 12 h） were observed. The blood lactate levels, white blood cell count, rehydration and vasoactive drug dosage before and after treatment （6 h） were compared between the two groups. Results All the patients showed decreased heart rate and increased mean arterial pressure after treatment. The change in the treatment group was significantly better than that in the control group （P 0.05）. In the treatment group, the volume of fluid infusion and blood lactate levels of vasoactive drugs 6 h after treatment were significantly lower than those in the control group （P〈0.05）. Conclusion In patients with septic shock, Shenmai injection can significantly elevate the mean arterial pressure, slower the heart rate, reduce the blood lactate levels, improve tissue perfusion, and reduce the volume of fluid replacement and vasoactive drug dosage.