低剂量糖皮质激素吸入治疗的持续时间对哮喘患儿预后的影响

Effect of the treatment duration of low dose inhaled corticosteroids on the prognosis of children with asthma

目的探究低剂量糖皮质激素吸入治疗的持续时间对哮喘患儿预后的影响。方法选取我院于2008年1月至2010年2月收治的93例哮喘患儿,在其监护人知情同意的前提下对其进行平均分组,按照治疗时间分为1月组(n=31)、半年组(n=31)及1年组(n=31),并根据组别制定低剂量糖皮质激素吸入治疗疗程方案,并于疗程结束后对比三组患儿的最大呼气峰流速(PEF)及两年复发情况。结果疗程结束后,三组患儿平均PEF分别上升至90.1%、90.5%和90.3%,差异无明显统计学意义;三组患儿的两年复发率分别为67.7%、22.6%和6.5%,随着治疗持续时间的增加,患儿复发率明显降低。结论采取低剂量糖皮质激素长时间吸入能够在不影响患儿生长发育的前提下显著降低复发率,值得临床广泛推广。

Objective To explore the treatment duration of low dose inhaled glucocorticoid on the prognosis of children with asthma. Methods Ninety-three children with asthma treated in our hospital from January 2008 to February 2010 were enrolled in the study. The patients were divided equally into three groups based on the treatment duration： one month group （n=31）, half an year group （n=31） and one year group （n=31）. The children＇s peak expiratory flow （PEF） and two-year recurrence rate were compared between the three groups. Results After treatment, the average PEF of the three groups were increased to 90.1%, 90.5% and 90.3%, respectively, with no statistically significant difference between. The two-year recurrence rates of the three groups were 67.7%, 22.6% and 6.5%, respectively. The recurrence rate was significantly reduced as the increase of the treatment duration. Conclusion The use of low dose inhaled glucocorticoid in long time can greatly reduce the relapse rate, without affecting the growth and development of children, which is worthy of clinical application.