胃癌患者凝血功能和D-二聚体水平的变化及其临床意义

Change of coagulation function and D-dimer in patients with gastric cancer and its clinical significance

目的探讨凝血功能和D-二聚体水平在胃癌患者中的检测价值。方法选择我院胃癌患者40例作为观察组,上述患者均经体格检查、影像学检查、病理组织学检查等确诊。选择同期健康体检者40例作为对照组。本文所选对象均取清晨空腹抗凝血浆测定凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、凝血酶时间(TT)、纤维蛋白原(Fib)和D-二聚体(D-D)水平。结果胃癌组PT、APTT较对照组延长,差异有统计学意义(均P<0.05);TT较对照组长,但差异无统计学意义(P>0.05);观察组Fib、D-二聚体水平较对照组明显升高,差异有统计学意义(均P<0.01)。结论胃癌患者凝血功能发生紊乱,检测相关凝血功能指标及D-二聚体水平对其病情观察和临床治疗具有一定的指导意义。

Objective To explore the clinical significance of coagulation function and D-dimer （D-D） in patients with gastric cancer. Methods The plasma prothrombin time （PT）, activated partial thromboplastin time （APTT）, thrombin time （TT）, fibrinogen （Fib） and D-D were determined in 40 healthy individuals （the control group） and in 40 patients with gastric cancer （the study group）. Results The plasma PT, APTT were significantly longer in the study group than the control group （P〈0.05）. TT of the study group was slightly longer than that of the control group, with no statistically significant difference （P〈0.05）. Fib and D-D levels of the study group were significantly higher than those of the control group （P〈0.01）. Conclusion Patients with gastric cancer exhibit disorder of coagulation function. The detection of coagulation function and D-D in patients with gastric cancer plays important role for the observation of disease condition and the clinical treatment.