HIV感染并发心血管疾病发病机制研究进展

Recent progress in researches on the pathogenesis of HIV infection complicated with CVD

随着高效抗反转录病毒治疗(HAART)的应用,心血管疾病(CVD)已经成为人类免疫缺陷病毒(HIV)感染者死亡的一个重要原因。据报道,HIV感染人群的CVD发病率至少是普通人群的3倍。因此,HIV感染并发CVD的发病机制成为艾滋病(AIDS)研究最关注的领域之一。现对HIV感染者独特的CVD危险因素及宿主、HIV和抗反转录病毒药物等三个方面致病机制研究的最新进展做一简要综述。

With the application of highly active antiretroviral therapy（HAART）,cardiovascular disease（CVD） has become an importance cause of morbidity and mortality among HIV-infected people.It is reported that the incidence of CVD in HIV-infected people is at least three times higher than in the general population.Therefore,the pathogenesis of HIV infection complicated with CVD has become one of the hottest topics in public health.This article describes recent progress in researches on the specific risk to CVD in HIV-infected people in comparison with that among uninfected people and the relative contributions of hosts,HIV and antiretroviral drugs to the pathogenesis of CVD in the light of current knowledge.