盐酸美金刚治疗阿尔茨海默病的疗效与安全性

Efficacy and Safety of Memantine for Alzheimer's Disease

目的:观察盐酸美金刚治疗阿尔茨海默病(AD)的疗效与安全性。方法:将104例AD患者以随机表法分为对照组52例和治疗组52例。对照组运用茴拉西坦、银杏叶胶囊进行常规治疗,治疗组在常规治疗的基础上每日加服盐酸美金刚20 mg。以简易智能状态检查量表(MMSE)、日常生活能力量表(ADL)分别作为主要评价指标,比较2组患者在治疗前与治疗3、6、12个月后的认知能力、日常生活能力的情况。结果:治疗组患者MMSE评分在3个月后、ADL评分在6个月后优于对照组,差异有统计学意义(t分别为2.361、-2.40,P分别<0.05、0.01);治疗组患者12个月时2个指标显著优于对照组,差异有统计学意义(均P<0.01)。结论:盐酸美金刚治疗AD的疗效满意、安全可靠,可有效减缓AD患者认知功能和日常生活能力的衰退进程。

OBJECTIVE：To evaluate the efficacy and safety of memantine in treating patients with Alzheimer＇ s disease（AD）. METHDOS： Totally 104 patients with AD were randomly assigned to receive routine therapy （aniracetam plus ginkgo biloba leaves extract capsules, control group, n = 52） alone or in combination with add-on memantine （20 mg daily） （treatment group, n = 52）. The improvement in cognitive ability and activities of daily life were compared between the two groups at 0, 3, 6 and 12 months using mini-mental state examination （MMSE） scale and the activity of daily living （ADL） scale, respectively. RESULTS： The MMSE scores at 3 months and ADL score at 6 months were significantly better in treatment group than in control group （t =2. 361, -2. 40; P 〈0. 05 or P 〈0. 01 ） ; at 12 months, both the MMSE scores and the ADL scores were significantly better in the treatment group than in the control group （all P 〈0. 01 ）. CONCLUSION： Menantine hydrochloride was proved to be effective, safe and reliable for patients with AD in that it slowed down patients＇ deterioration in cognitive ability and activity of daily living.