摘要
目的:分析药品不良反应(ADR)发生的特点及临床表现,为临床合理用药提供参考。方法:利用Excel电子表格对2008—2012年我院收集上报的136例ADR报告中患者的性别、年龄、涉及药物类别、给药途径、ADR累及器官和(或)系统进行统计分析。结果:136例ADR中,抗菌药物引起ADR最为多见,有66例次,占48.53%,其次为中药注射剂55例次,占40.44%;给药途径方面,静脉给药致ADR为130例,占95.59%;ADR累及器官和(或)系统主要为神经系统(75例次,占37.88%)、皮肤及其附件(51例次,占25.76%)。结论:应严格按照《抗菌药物临床应用指导原则》合理使用抗菌药物,规范中药注射剂的临床应用,保障患者用药安全、有效。
OBJECTIVE:To analyze the characteristics and clinical manifestation of the adverse drug reactions (ADRs) occurred in our hospital so as to provide reference for clinical rational drug use. METHODS: Using Excel spreadsheet, 136 ADR cases reported by our hospital during 2008-2012 were analyzed statistically with regard to patients' age and sex, the drug categories involved, route of administration, and organ and (or systems) involved. RESULTS: Of all the drugs induced the 136 ADR cases, antibacterial drugs took the lead with 66 cases (48.53%) , followed by traditional Chinese medicine injection with 55 cases (40.44%). Regarding the route of administration, 130 (95.59%) were induced by intravenous route. Regarding the organs and or (systems) involved, nervous system lesions took the lead with 75 (37.88%) followed by lesions of skin and its accessories with 51 (25.76%). CONCLUSION: The antibacterials should be used rationally by strictly follow the Guiding Principle of Clinical Application of Antibacterial Drugs order to ensure patients' safe and . It is urgent to standardize he clinical application of Chinese medicine injections in effective medication.
出处
《中国医院用药评价与分析》
2013年第3期263-265,共3页
Evaluation and Analysis of Drug-use in Hospitals of China
关键词
药品不良反应
抗菌药物
中药注射剂
合理用药
Adverse drug reaction
Antibacterials
Traditional Chinese medicine injection
Rational drug use