86例药品不良反应报告分析

Adverse Drug Reactions:Analysis of 86 Cases

目的:了解我院(大连市第六人民医院)药品不良反应(ADR)发生情况及特点,提示临床医师关注ADR,以促进临床合理用药。方法:对2009年5月—2012年6月我院上报至国家药品不良反应监测网的86例ADR报告中的各项数据进行回顾性分析。结果:86例ADR报告中,一般的ADR共81例,占94.19%,远高于严重的ADR;男性患者ADR发生率高于女性患者;40岁以上患者ADR发生率为81.40%(70/86),远高于年轻患者;静脉给药致ADR发生率为60.46%(52/86),高于肌内给药和口服给药;单一用药ADR发生率为77.91%(67/86),高于联合用药;引起ADR的相关药物以病毒性肝炎治疗药物为主,共47例(占54.65%),药品种类数为34种,占所有药品种类数的64.15%。结论:ADR的发生与多种因素有关,合理用药是降低ADR发生的关键。

OBJECTIVE ：To investigate the status quo and characteristics of the adverse drug reactions （ADRs） occurred in our hospital （Dalian The Sixth People＇ s Hospital） so as to call for clinicians＇ attention to the ADRs and promote clinical rational drug use. METHODS： A total of 86 ADR cases submitted by our hospital to national ADR monitoring network from May 2009 to June 2012 were retrospectively analyzed. RESULTS： Of the 86 ADR cases, there were far more general ADR cases[81 （94. 19% ） ~ than serious ADR cases; the ADRs were more often seen in males than in females and in patients aged over 40 years （81.39%, 70/86） rather than in younger patients, more often induced by intravenous administration （60. 46%, 52/86） than by intramuscular and oral administration and more often induced by single-drug therapy 77. 91% （67/86） rather than by drug combination. Among all the ADR-inducing drugs, the drugs for hepatitis took the lead which induced 47 ADR cases （54. 65% ）. The involved drugs totaled 34 kinds, accounting for 64. 15% of total drug types. CONCLUSION： The adverse drug reactions were associated with multiple factors and rational drug use is the key to reduce ADR incidence.