脐带间充质干细胞移植治疗50例缺血性下肢血管病的临床研究

The Clinical Research of Umbilical Cord Mesenchymal Stem Cells Transplantation in The Treatment of 50 Cases of Lower Limb Vascular Disease

目的:观察脐带间充质干细胞移植治疗缺血性下肢血管病的临床疗效并观察近期临床效果。方法:50例自愿接收脐带间充质干细胞移植患者中糖尿病足35例,动脉硬化闭塞症10例,血栓性闭塞性脉管炎5例。全部患者均给予静脉输注及局部种植脐带间充质干细胞。术后第7天至6个月定期观察各项指标的变化。结果:治疗1月后,47例(94%)疼痛有不同程度的缓解,46例(92%)患肢冷感明显缓解,45例(90%)患者行走距离延长。6月后30例糖尿病足患者溃疡或足部坏疽痊愈。结论:脐带间充质干细胞移植治疗缺血性下肢血管病是一种简便、安全、有效的治疗方法,其治疗的近期疗效显著,使很多患者免除截肢或降低截肢平面,明显改善患者生活质量。

Objective： To investigate the umbilical cord mesenchymal stem cells transplantation in the treatment of ischemic vascular disease the clinical curative effect of the lower limbs watching the recent clinical effect.Methods： Fifty patients with voluntary receiving umbilical cord mesenchymal stem cells transplantation in patients with diabetes foot 35 patients,arteriosclerosis block disease 10 cases,thrombosis obliterans 5 cases.All patients were given intravenous and local planting umbilical cord mesenchymal stem cells.Postoperative seven days to six months each index of change regularly observation.Results： 1 month after treatment,47 patients（94%） had different degrees of pain relief,46 cases（92%） limb cold feeling significant relief,45 patients（90%） patients walking distance to extend.After six months,30 cases of patients with diabetes foot ulcers or foot gangrene healed.Conclusions： Umbilical cord mesenchymal stem cells transplantation in the treatment of ischemic lower limb vascular disease is a simple,safe and effective in the treatment of method,the treatment of recent curative effect is distinct,making a lot of patients from amputation or reduce amputation plane,significantly improve the quality of life of the patients.