吸烟对氨氯地平降压疗效及NO、ET-1、baPWV的影响

The Effects of Smoking on the Antihypertensive Efficacy of Amlodipine and NO,ET-1,baPWV

目的:评价吸烟对氨氯地平的降压疗效以及对内皮功能和baPWV的影响。方法:120例轻中度高血压患者,根据吸烟情况分为吸烟组(n=60)和不吸烟组(n=60),所有患者服用氨氯地平(5 mg,Qd)12周。观察两组患者的降压疗效以及治疗前后NO、ET-1、baPWV的变化。结果:治疗12周后,吸烟组与不吸烟组的降压总有效率分别为53%、60%,两组比较无统计学差异;治疗前吸烟组与不吸烟组NO浓度分别为272.96±48.62(μmol/L)、318.42±44.17(μmol/L),ET-1浓度分别为432.22±50.78(μg/L)、342.75±43.81(μg/L),baPWV分别为1857.9±214.2(cm/s)、1630.3±110.0(cm/s),上述指标组间比较均有显著统计学差异(P<0.01);经治疗后上述指标较治疗前不吸烟组有统计学意义(治疗前后NO 318.42±44.17(μmol/L)vs 385.37±58.45(μmol/L);ET-1342.75±43.81(μg/L)vs 258.49±43.19(μg/L);baPWV 1630.3±110.0(cm/s)vs 1573.9±140.4(cm/s)),而吸烟组无统计学差异(治疗前后NO 272.96±48.62(μmol/L)vs 289.87±48.63(μmol/L);ET-1 432.22±50.78(μg/L)vs 423.31±47.43(μg/L);baPWV1857.9±214.2(cm/s)vs 1804.5±226.1(cm/s))。结论:吸烟对氨氯地平降压疗效无明显影响,但吸烟影响氨氯地平改善内皮功能及baPWV的作用。

Objective： To evaluate the effects of smoking on the antihypertensive efficacy of amlodipine and endothelial function and baPWV.Methods： According to smoking status,120 patients with mild to moderate hypertensive patients were divided into smoking group（n=60） and non-smoking group（n=60）,and all patients took amlodipine（5 mg,Qd） for 12 weeks.Antihypertensive effect and NO,ET-1,baPWV were observed before and after treatment.Results： 12 weeks after treatment,the total effective rate of smoking group and non-smoking group was 53 %,60 % respectively,but there was no significant difference between the two groups.Before treatment,the concentration of NO in the smoking group and non-smoking group were 272.96±48.62（μmol/L） and 318.42±44.17（μmol/L） respectively,the ET-1 were 432.22±50.78（μg/L） and 342.75±43.81（μg/L） respectively,and baPWV were 1857.9±214.2（cm/s） and 1630.3±110.0（cm/s）,respectively.Compared with pre-treatment,the above indicators of non-smokers after treatment had statistical differences（NO 318.42±44.17（μmol/L） vs 385.37±58.45（μmol/L）,ET-1 342.75±43.81（μg/L） vs 258.49±43.19（μg/L）,baPWV 1630.3±110.0（cm/s） vs 1573.9±140.4（cm/s））,but the smoking group had no statistical difference（NO 272.96±48.62（μmol/L） vs 289.87±48.63（μmol/L）,ET-1 432.22±50.78（μg/L） vs 423.31±47.43（μg/L）,baPWV 1857.9±214.2（cm/s） vs 1804.5±226.1（cm/s））.Conclusion： Smoking has no significant influence on antihypertensive therapy of amlodipine,but smoking can affect its effects of improving endothelial function and baPWV.