摘要
目的:探讨定量分析在SPECT脑99mTc-ECD显像检测系统性红斑狼疮(SLE)脑病中的应用价值和目测分析与定量分析方法的相关性。方法:选择年龄匹配的健康人作比较,分别对33例SLE患者和29例正常对照进行SPECT脑血流灌注显像,采用肉眼读片分析及定量分析进行评价,BS软件进行分析。结果:狼疮脑病患者99mTc-ECD显像有脑血流改变,多表现为局部脑血流降低。肉眼读片分析SPECT诊断的SLE脑部受损的阳性率为51.51%,定量分析的阳性率达57.57%。成组t检验示扣带回、颞顶叶等部位最常受累。结论:SPECT脑血流灌注显像可探查到脑组织代谢和功能性损伤以及血流灌注变化,有助于发现SLE患者脑部血流受损情况。联合应用SPECT脑功能显像及BS分析软件可以更方便、快捷地定位大脑功能受损区。视觉分析与定量分析方法有很高的相关性。SPECT脑血流灌注显像对SLE脑病的诊断、治疗有重要的临床价值。
Objective： To elucidate a method for the quantitative analysis in 99mTc-ECD brain SPECT imaging of neuropsychia-tric in systemic lupus erythematosus and the correlation of visual and quantitative analysis.Methods： 99mTc-ECD SPECT imaging was performed in 33 SLE patients and 29 controls.The results were analyzed by visual and quantitative comparison.The images were ana-lyzed with brain search（BS）.Results： The change of cerebral blood flow,especially decreases in regional cerebral blood flow were asso-ciated with serious neuropsychiatric SLE presentations.Cingulate gyrus and temporal-parietal were most involved areas under unpaired t-test.The positive rate of SPECT imaging by visual and quantitative analysis was respectively 51.51%,and 57.57%.The method of quantitative and visual analysis had high correlation.Conclusions： 99mTc-ECD SPECT could easily demonstrate metabolic,functional lesions and cerebral blood flow change without structural abnormalities.The sensitivity of cerebral blood flow perfusion SPECT imaging was high,but lack of specificity.The combination of brain perfusion SPECT and brain search（BS） was a convenient and shortcut method to align the disfunctional areas of the brain.99Tcm-ECD SPECT was a useful and objective method for detecting perfusion abnormalities in SLE patients.
出处
《现代生物医学进展》
CAS
2013年第4期701-704,共4页
Progress in Modern Biomedicine
基金
江苏省南京市医学重点科技发展项目(ZKM05044)
