布拉氏酵母菌联合PPI三联疗法治疗幽门螺杆菌性消化性溃疡的临床疗效观察

Clinical Efficacy of Saccharomyces Boulardii Combined with PPI Rriple Rherapy on Patients with Helicobacter Pylori Peptic Ulcer

目的:观察布拉氏酵母菌联合PPI三联疗法治疗幽门螺杆菌性消化性溃疡的临床疗效及安全性。方法:100例Hp阳性消化性溃疡患者随机分为治疗组和对照组,对照组给予常规PPI三联疗效治疗(奥美拉唑+阿莫西林+克拉霉素),治疗组在常规PPI三联疗法的基础上给予布拉氏酵母菌,疗程结束后评价临床疗效,观察治疗期间的药物不良反应,检测胃液pH值,对胃液细菌进行培养,检测Hp抑杀情况,评定消化性溃疡复发。结果:治疗组临床疗效有效率(96.0%)、Hp抑杀率(84.4%)均显著高于对照组(62.0%、64.4%),两组比较有显著性差异(x2=6.899、5.848,P<0.05)。治疗后,治疗组胃液pH值、胃液细菌培养阳性率与治疗前和对照组比较均明显升高(P<0.05);随访1年,治疗组复发率为10.0%,对照组为26.0%,两组复发率比较有显著性差异(x2=11.584,P<0.05)。两组均无严重不良反应发生。结论:布拉氏酵母菌联合PPI三联疗法治疗Hp阳性消化性溃疡临床疗效好,复发率低,且安全可靠,值得临床应用。

Objective： To observe the clinical efficacy and safety of saccharomyces boulardii combined with PPI triple therapy for treating the patients with helicobacter pylori（Hp） peptic ulcer.Methods： 100 cases of patients with Hp peptic ulcer were randomly divided into treatment group and control group.The control group was given the PPI triple therapy（omeprazole,amoxicillin and clarithromycin）,the treatment group was given the saccharomyces boulardii combined with PPI triple therapy.The clinical efficacy was evaluated after treatment,the adverse reactions were observed,the gastric pH value was detected,the gastric juice bacterial was cultured,the Hp inhibit-ed and killed were detected,the peptic ulcer recurrence was evaluated.Results： The clinical efficacy（96.0%） and Hp inhibited and killed（84.4%） of the treatment group were significantly higher than that of the control group（62.0% and 64.4%）,the difference between the two groups was significant（x2= 6.899,5.848,P0.05）.After treatment,the gastric pH value,positive rate of gastric juice bacterial of the treatment group significantly increased,comparing with the pre-treatment and control group the difference was significant（P 0.05）;1 year follow-up,the recurrence rate of the treatment group was 10.0% and the control group was 26.0%,the recurrence rate between the two groups was significantly different（x2=11.584,P0.05）.No serious adverse events occurred.Conclusion： The saccharomyces boulardii combined with PPI triple therapy for treating the patients with Hp peptic ulcer has good clinical efficacy,the recurrence rate is low.It is safe and reliable treatment program,and worthy of clinical application.