舌鳞状细胞癌中血管生成拟态的临床意义

Vasculogenic mimicry in tongue squamous cell carcinoma

目的探讨舌鳞状细胞癌组织中血管生成拟态(VM)存在的临床意义。方法筛选42例舌鳞状细胞癌患者石蜡标本,进行HE染色及CD34免疫组化染色结合过碘酸雪夫氏(Periodic acid-Schiff,PAS)双重染色检测舌鳞状细胞癌中的VM。结果在42例舌鳞状细胞癌患者,存在VM的比例为42.86%(18/42),与患者性别、年龄无关,与淋巴结转移、肿瘤组织分化程度有关,有VM组的舌鳞状细胞癌淋巴结转移阳性率高于无VM组(P<0.05),有VM组的舌鳞状细胞癌组的分化程度低于无VM组(P<0.05),差异有统计学意义。结论舌鳞状细胞癌中存在VM,组织分化程度越低的舌鳞状细胞癌形成VM的能力越强,易发生转移,预后差。

Objective To investigate the presence of vasculogenic mimicry（VM） in tongue squamous cell carcinoma and explore its clinical significance.Methods Forty-two surgical specimens of tongue squamous cell carcinoma were examined for the presence of VM using HE staining and double staining of CD34 and PAS.Results Of the 42 specimens,18（42.86%） showed the presence of VM.VM was not correlated with the patients’ age or gender,but with lymph node metastasis and the grade of tumor differentiation.Compared with tumors without VM,the tumors with VM had a significantly higher rate of lymph node metastasis（P0.05） and a lower grade of differentiation（P0.05）.Conclusion VM can be present in tongue squamous cell carcinoma,and the poorly differentiated tumors contain more VM,which is associated with a greater likeliness of lymph node metastasis and a poorer prognosis.