复方氨基酸注射液(17AA-H)在肝功能不全病人中的应用研究

Applied research of compound amino acid injection(17AA-H) in hepatic insufficiency patients

目的:评价复方氨基酸注射液(17AA-H)对肝功能不全病人的营养支持效果及对肝功能恢复的影响。方法:选择肝功能不全病人59例,给予肠外营养(PN)支持,采用回顾性非随机对照研究方法,根据氮源的不同分为两组。研究组29例使用复方氨基酸注射液(17AA-H),对照组30例使用复方氨基酸注射液(18AA-Ⅱ)。比较两组病人PN前后营养指标(总蛋白、清蛋白)、肝功能指标(谷丙转氨酶、谷草转氨酶、总胆红素、直接胆红素、碱性磷酸酶、γ-谷氨酸转肽酶)等变化。结果:两组病人PN支持后营养指标均有所改善,总蛋白、清蛋白组内比较有显著性差异(P<0.05)。研究组病人谷丙转氨酶、谷草转氨酶、总胆红素等有所恢复,前后比较有显著性差异(P<0.05)。结论:使用17AA-H作为PN氮源,有助于改善肝功能不全病人的营养状况和肝功能恢复。

Objective： To investigate of efficacy of compound amino acid injection （17AA-H） on hepatic insufficiency. Methods： Totally 59 patients were selected for retrospective non-randomized control study： research group and control group. Both group received parenteral nutrition （PN）. Patients in the research group received compound amino acid injection （17AA-H） ,and those in the control group received compound amino acid injection （18AA-Ⅱ ）. The two groups were compared with the following factors ： nutrition index （ total protein, albumin ） and liver function （ aspartate aminotransferase, alanine aminotransferase, total bilirubin, direct bilirubin, alkaline phosphatase, γ-glutamate-transpeptidase）. Results ： After PN, the study group and the control group of nutritional indexes were improved, and total protein and albumin group difference had statistic significance （ P 〈 0.05 ）, but no differences were showed between the groups （P 〉 0.05 ）. The study group got a better recovery of liver function and alanine transaminase, aspartate aminotransferase and total bilirubin group difference had statistic significance （P 〈0.05）. Conclution： PN containing compound amino acid injection （17AA-H） can effec- tively improve the patients＇ nutrition and liver function with hepatic insufficiency.