阳和汤联合光动力学外照射疗法对糖尿病足大鼠治疗作用及SIL-2R的影响

The united effects of photodynamic therapy and aoup yanghetang upon SIL-2R of the rats with diabetic foot

目的:观察阳和汤联合光动力学外照射疗法对糖尿病足大鼠的治疗作用及对可溶性白介素2受体(SIL-2R)的影响。方法:在用链脲佐菌素(STZ)建立糖尿病模型的基础上,通过游泳,冰块降温和液氮冷冻,诱导糖尿病足大鼠模型,约3周时间建立模型。把造模成功的大鼠随机分为光动力治疗加阳和汤组、光动力治疗组、莫匹罗星组、糖尿病足模型组、阳和汤组、空白对照组,每组10只。结果:大鼠体重变化、饮水量监测、糖尿病足评分和血液流变学检测结果提示光动力治疗加阳和汤组与其他治疗组之间各指标有统计学差异。血清SIL-2R值模型组与其他组有明显差别(P<0.01),光动力治疗加阳和汤组与光动力治疗组、阳和汤组、莫匹罗星组各组均有明显差别(P<0.01),光动力治疗加阳和汤组与光动力治疗组没有明显差别(P>0.05)。结论:光动力学联合阳和汤对糖尿病足大鼠的疗效优于其他治疗组,溃疡愈合最明显。

AIM： To observe the united effects of photodynamic therapy and soup yang- hetang upon soluble interleukin-2 receptor （SIL- 2R） of the rats with diabetic foot. METHODS. On the basis of diabetes model by STZ, to estab- lish diabetic loots model through swimming, ice- cubed reducing the heat and liquid nitrogen freezing, which took about 3 weeks divide ex- perimental model of rat into six groups in which 2 groups were respectively treated by He-Ne la- ser and improved dressing, only He-Ne laser, only improved dressing and Mupirocin, while the model group and normal group had no treat- ment. Every group was 10 respectively. RE- SULTS： There were significant difference with changes in the body weight of rats, the amount of drinking water, the score of diabetic foot and the results of blood rheology prompted the group of photodynamic therapy and soup yanghetangwith other treatment group. The united effects of photodynamic therapy and soup yanghetang to SIL-2R was distinguished from the normal group, the model and the other the treatment groups （P〈0.01）. However, it had no differ- ence from the photodynamic therapy group （P〉 0.05）. CONCLUSION. The method of the pho- todynamic therapy diabetic and improved dress- ing on diabetic foots treatment has the lowest sIL-2R and the most significant ulcer healing. It may provides experimental proof and theoretical basis to further clinic treatment, which has in- creased a medical treatment and technological method in order to treat diabetic loots.