四种药物治疗细菌性阴道炎的药物经济学评价

The pharmacoeconomic evaluations of four drugs in the treatment of bacterial vaginitis

目的探讨硝呋太尔制霉素栓、乳酸菌阴道胶囊、双唑泰阴道泡腾片及聚甲酚醛栓四种药物治疗细菌性阴道炎的成本效果，为临床合理用药提供指导。方法随机选取分别使用硝呋太尔制霉素栓（92例）、乳酸菌阴道胶囊（88例）、双唑泰阴道泡腾片（90例）及聚甲酚醛栓（91例）治疗的细菌性阴道炎门诊患者361例，比较用药一个疗程的治疗效果、用药成本及不良反应，运用药物经济学成本．效果分析法评价四种治疗方案的成本效果。结果硝呋太尔制霉素栓、乳酸菌阴道胶囊、双唑泰阴道泡腾片及聚甲酚醛栓总有效率分别为78．26％、76．14％、83．33％、78．02％，四组总有效率差异无统计学意义（P〉0．05）；双唑泰阴道泡腾片具有最小的成本一效果比（C／E，0．26）。结论从药物经济学角度来看，双唑泰阴道泡腾片是治疗细菌性阴道炎的较佳选择。

Objective To investigate the cost-effectiveness of four drugs in treatment of bacterial vaginitis and improve clinic rational drug use. Methods 361 bacterial vaginitis out-patients were treated with lactobacillus vaginal effervescent tablets（92 cases）, lacidophilin vaginal capsules （88 cases）, shuangzuotai vaginal effervescent tablets （90 cases）, metronidazole vaginal effervescent tablets （91 cases）. The therapeutic effect, drug cost and therapeutic effect were evaluated by cost effectiveness analysis 7d after treatment. Results The overall response rate of lactoba- cillus vaginal effervescent tablets, lacidophilin vaginal capsules, shuangzuotai vaginal effervescent tablets, metronidazole vaginal effervescent tablets were 78.26% ,76.14% , 83.33 % and 78.02%, respectively. The overall response rate was no significant difference between four groups（0.06）, and metronidazole vaginal effervescent tablets had the lowest cost effectiveness rate （ C/E, 0. 26）. Conclusion The metronidazole vaginal effervescent tablets is better schedule in treatment of bacterial vaginitis.