ICP-MS直接测定儿童全血中铅及其同位素比值

Direct determination of lead and its isotope ratio in childhood whole blood by inductively coupled plasma mass spectrometry

目的:建立全血中铅及其同位素比值的分析方法。方法:全血经稀释20倍后直接用ICP-MS进行分析。结果:总铅的测定的精密度优于1.1%、检出限小于1 ng/ml,加标回收为96.0%～102%;207Pb/206Pb和208Pb/206Pb同位素比值测定的精密度优于0.13%,标准物质的分析结果和证书值一致。结论:可采用ICP-MS准确测定儿童全血品中的铅及其同位素比值,方法简便、快速、准确。

Objective：To develop a method for determination of lead and its isotope ratio in childhood whole blood by inductively coupled plasma mass spectrometry. Methods： The samples were directly determined by inductively coupled plasma mass spectrometry after 20 - fold dilution. Results： As to lead determination, the precision was better than 1.1%, the detection limit was under 1 ng/ml, and the recovery was between 96.0% - 102%. As to ^207Tpb/^206pb and^208Pb/^206Pb, the determination precision was 0.13%, the results were in consistency with the stand- ard. Condusion： This method is simple, sensitive and accuracy, and can determinte lead and its isotope ratio in childhood whole blood.