北京市顺义区在校学生接种甲型H1N1流感疫苗前后抗体水平监测

Surveillance on the antibody levels of the students before and after vaccination with influenza A(H1N1) vaccines in Shunyi district of Beijing

目的:了解北京市顺义区在校学生接种甲型H1N1流感疫苗前后的抗体水平,为卫生部门制定防控措施提供依据。方法:随机选取4个乡街的学生,监测接种甲型H1N1流感疫苗前后的抗体水平。结果:46份免疫前血清标本中甲型H1N1流感抗体水平阳性率58.70%(27/46),与北京市人群甲型H1N1流感抗体水平检测结果有差别(P<0.05),抗体几何平均滴度倒数(GMRT)41.2。免疫后抗体阳性率89.1%(41/46),抗体阳转率78.26%(36/46)。46对血清抗体滴度总体呈9倍增高,免疫后GMRT为380.55。不同性别学生之间免疫后抗体水平阳性率无差别(χ2=0.00,P>0.05),小学组和中学组之间抗体水平阳转率无差别(χ2=0.049,P>0.05)。结论:顺义区在校学生可能有一半以上曾感染甲型H1N1流感,感染与性别无关,与年龄有关,中学组感染率高于小学组。甲型H1N1流感流行期间接种疫苗是控制学校疫情的必要手段。

Objective：To observe the antibody levels of the students before and after vaccination with influenza A （ H1 N1 ） vaccines in Shunyi district of Beijing, to provide a scientific evidence for making the prevention and control strategies of influenza A（ H1N1 ） by related departments. Methods： Students were randomly selected from 4 towns and streets to monitor the antibody levels before and after vaccination of influenza A（ H1 N1 ） vaccine. Results： Be- fore immunization, the positive rate of influenza A（ H1 N1 ） antibody in 46 serum specimens was 58.70% （27/46）, which had no difference with that of population in Beijing（P 〈 0.05 ）. The reciprocal geometric mean antibody titers （GMRT） was 41.2, the seroconversion rate was 78.26% , the GMRT was 380.55 after vaccination, there was no significant difference in the positive rate after immunization between different sexes （X^2 = 0.00, P 〉 0.05 ） and sero- conversion rate between primary and secondary school students （X2 = 0. 049, P 〉 0.05 ）. The antibody titer was 9 times increasing. Conclusion： The incidence of influenza A（ H1N1 ） in students in Shunyi District was more than 1/2, the incidence was unrelated to sex but related to age, higher in secondary students than that of the primary school students. The vaccination was necessary means to control the influenza A（ H1N1 ） in school.