佛山地区先天性甲状腺功能减低症发病趋势分析

Analysis on the trend of congenital hypothyroidism in Foshan

目的了解佛山地区先天性甲状腺功能减低症(congenital hypothyroidism,CH)的发病趋势。方法分析佛山地区2000年～2011年CH的筛查结果。收集佛山地区新生儿生后72h后-7天内足跟血滤纸干血片,采用荧光免疫法检测促甲状腺激素(TSH)水平进行CH筛查,筛查阳性病例采用化学发光法检测血清中游离三碘甲状腺原氨酸(FT3)、游离甲状腺素(FT4)及TSH水平,确诊病例按疾病诊疗常规进行治疗和随访。结果佛山地区2000年6月开始实行新生儿疾病筛查,2000年6月～2011年12年间共筛查新生儿621 244例,确诊CH 341例,总发病率为1/1822。2000年～2003年CH发病率为1/1515,2004年～2007年CH发病率为1/1602,2008年～2011年CH发病率为1/2177。2008年～2011年CH发病率较2004年～2007年有明显下降,差异有统计学意义(P<0.05)。结论佛山地区CH发病率呈下降趋势,可能与育龄妇女围产保健意识增强,以及孕期环境改善等因素有关。

Objective： To study the trend of congenital hypothyroidism （CH） in Foshan. Methods： To analysis the newborn screening results of CH from 2000 to June 2011 in Foshan. To collect the dry blood spot filter paper of newborns in Foshan, Infants with elevated TSH level higher than 10 mIU/ L were recalled for testing the serum FT3 , FT4 and TSH, infants with CH were treated and followed - up in the newborn screening center. Results ： newborn screening was carried out since June 2000 in Foshan, from June 2000 to 2011,621 244 infants had accepted newborn screening, 341 infants with CH were diagnosed, the total incidence of CH in Foshan was 1/1822, the incidence of CH was 1/1515 from 2000 to 2003, the incidence of CH was 1/1602 from 2004 to 2007, the incidence of CH was 1/2177 from 2008 to 2011. the incidence of 2008 to 2011 was significant lower than that in the 2004 to 2007 （P 〈 0.05 ）. Conclusions ： the incidence of congenital hypothyroidism in Foshan city presented downward trend, it maybe owed to the factors such as the consciousness of perinatal health care was strengthened in the women of childbearing age, and the environments of pregnancy improved.