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系统性红斑狼疮的情绪及认知功能障碍与5-羟色胺系统的关系 被引量:1

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摘要 系统性红斑狼疮(systemic lupus erythematosus,SLE)是一种经典的自身免疫病,主要累及皮肤、关节、肾脏、血液系统和神经精神系统等,其引起中枢、周围、自主神经系统及神经精神症状称为神经精神狼疮(neuropsychiatric systemi clupus erythematosus,NPSLE)。中枢神经系统5-羟色胺(5-hydrox-ytryptamine,5-HT)的神经核团位于中脑中缝核,广泛投射到大脑皮层,通过5-羟色胺受体调节人的生理功能、睡眠、情绪及应激反应。许多精神性疾病如抑郁症、认知功能障碍、焦虑症等与5-羟色胺有关,同时5-羟色胺也参与免疫调节。
出处 《中华风湿病学杂志》 CAS CSCD 北大核心 2013年第4期271-273,共3页 Chinese Journal of Rheumatology
基金 国家自然科学基金(81160379) 云南省应用基础研究计划项目联合专项(2011FBl67)
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