生脉散超微粉的显微特征和溶出度研究

Micro-characteristic and dissolution of ultra-micro Shengmai Powder

目的研究生脉散超微粉的显微特征和溶出度差异,为生脉超微粉应用提供实验依据。方法采用光学显微镜观察颗粒显微结构;电镜扫描观察微观形貌;以五味子甲素和五味子乙素为指标,采用HPLC法测定生脉散细粉和超微粉在不同时间溶出的量,计算累积溶出度。结果生脉散经超微粉碎后,基本无完整细胞存在,粒度均匀;生脉散超微粉中五味子甲素和五味子乙素溶出速率高于细粉,但是180min后累积溶出量没有明显差异。结论超微粉碎可使生脉散显微特征变化明显,化学成分五味子甲素和五味子乙素溶出速率加快。

Objective To study the micro-characteristic and dissolution of ultra-micro powder in Shengmai Powder,and to provide experimental foundation for the application of ultra-micro powder in Shengmai Powder.Methods The microstructure was observed by light microscope and the micro shape was observed by.electron microscope scanning.The dissolutions of Shengmai Powder and ultra-micro powder in Shengmai Powder at different time were determined by HPLC using schizandrins A and B as indexes.Results Compared with the common powder,the cellules of ultra-micro powder were pulverized,and the particles were tiny without intact cells and uniform.The cumulative dissolution rates of schizandrins A and B in ultra-micro powder were higher than those in the traditional common powder,but there was no significant difference after 180 min.Conclusion The micro-characteristic of ultra-micro powder in Shengmai Powder is obviously changed after ultrafine grinding,and the dissolution velocity of schizandrins A and B increases.