利奈唑胺致不良反应44例文献分析

Document analysis on 44 cases of adverse drug reaction induced by linezolid

目的探讨利奈唑胺所致不良反应的特点及相关因素,为临床合理用药提供参考。方法检索2000年1月—2012年11月国内医药期刊报道的44例利奈唑胺致不良反应案例,并进行统计、分析。结果利奈唑胺所致不良反应主要体现在血液、心血管及消化系统等,并且老年患者更易发生。结论临床应加强对利奈唑胺的合理使用,尽量避免或减少其所致不良反应的发生。

Objective To study the characteristics and related factors of the adverse drug reaction（ADR） induced by linezolid,so as to provide the references for the rational use of drugs in clinic.Methods Forty-four cases of ADR induced by linezolid,which were reported in domestic medical academic journals from January 2000 to November 2012,were statistically analyzed.Results The ADR induced by linezolid occured mainly in blood system,cardiovascular system,digestive system,and so on,at the same time,most of cases occurred in senile patients.Conclusion The rational use of linezolid should be emphasized to avoid or reduce the incidence of ADR.