摘要
Cyclic ADP-ribose (cADPR) is a universal Ca2+ mobilizing second messenger in many different cell types and organisms. cADPR activates Ca2+ release from endo/sarcoplasmic reticulum via ryanodine receptors. In addition, Ca2+ entry secondary to Ca2+ depletion is at least one of the mechanisms in which cADPR triggers Ca2+ inflow, too. Analogues of cADPR have been prepared by chemical and chemo-enzymatic routes. Most of the analogues were analyzed for biological activity in intact or permeabilized Jurkat T cells (a human T-lymphoma cell line). As a systematic approach, analogues were grouped according to alterations in the base, the northern ribose, the southern ribose, the pyrophosphate backbone, or in complex modifications, comprising more than one part of the molecule. Biological activity of the analogues is reviewed, with special emphasis on Jurkat T cells.
Cyclic ADP-ribose （cADPR） is a universal Ca2＋ mobilizing second messenger in many different cell types and organisms. cADPR activates Ca2＋ release from endo/sarcoplasmic reticulum via ryanodine receptors. In addition, Ca2＋ entry secondary to Ca2＋ depletion is at least one of the mechanisms in which cADPR triggers Ca2＋ inflow, too. Analogues of cADPR have been prepared by chemical and chemo-enzymatic routes. Most of the analogues were analyzed for biological activity in intact or permeabilized Jurkat T cells （a human T-lymphoma cell line）. As a systematic approach, analogues were grouped according to alterations in the base, the northern ribose, the southern ribose, the pyrophosphate backbone, or in complex modifications, comprising more than one part of the molecule. Biological activity of the analogues is reviewed, with special emphasis on Jurkat T cells.
基金
supported over the past couple of years by the Deutsche Forschungsge-meinschaft
the Gemeinnützige Hertie-Stiftung
the Well-come Trust
the Deutsche Akademische Austauschdienst
