土耳其海绵Ircinia variabilis中溴代生物碱的分离与鉴定

Isolation and identification of brominated alkaloids from the Turkish sponge Ircinia variabilis

目的研究土耳其海绵Ircinia variabilis的化学成分。方法采用多种色谱方法分离纯化,依据理化性质、波谱数据和文献对照的方法鉴定结构。结果从土耳其海绵Ircinia Variabilis提取物中分离鉴定了5个溴代生物碱类化合物:fistularin-3(1),2-oxazolidinone(2),(E)-1-acetamide-3,5-dibromo-4-ethoxy-4-methoxy-1-hydroxy-2,5-cyclohexaddienone(3),(Z)-1-acetamide-3,5-dibromo-4-ethoxy-4-methoxy-1-hydroxy-2,5-cyclohexaddienone(4),3,5-dibromotyrosine(5)。结论化合物1从该种内首次分离得到,化合物2～4从该种属中首次分离得到。

Objective To study the chemical constituents of the marine sponge Ircinia variabilis collected from the Turgut Reis coast.Methods The chemical constituents were isolated by various methods of isolation and their structures were elucidated by physicochemical properties and the analysis of spectral data compared with those reported in literatures.Results Five alkaloids were isolated and identified as fistularin-3（1）,2-oxazolidinone（2）,（E）-1-acetamide-3,5-dibromo-4-ethoxy4-methoxy-1-Hydroxy-2,5-cyclohexaddienone（3）,（Z）-1-acetamide-3,5-dibromo-4-ethoxy-4-methoxy-1-hydroxy-2,5-cyclohexaddienone（4）,and 3,5-dibromotyrosine（5）.Conclusion Compound 2-4 have benn isolated from the sponge Ircinia variabilis for the first time.