盐酸戊乙奎醚对大鼠体外循环转流期间微循环的影响

The effects of penehyclidine hydrochloride on mice microcirculation during extracorporeal circulation

目的:探讨盐酸戊乙奎醚(PHC)对大鼠体外循环期间微循环的影响。方法:选择健康成年SD大鼠20只,随机分为对照组(C组)、盐酸戊乙奎醚组(P组)。P组在预充液中加入PHC0.05mg/kg,C组加入等容量生理盐水;两组大鼠在体外循环建立后开始转流,转流时间为2h。观察时间点为:T0:转流前;T1:体外循环转流开始后1h;T2:体外循环转流开始后2h。分别在3个时间点观察两组大鼠的血压、心率、动静脉血氧分压差(Pa-vO2)、乳酸含量、转流2h总尿量。结果:T2、T3时刻P组大鼠乳酸含量低于C组,动静脉血氧分压差、转流2h总尿量高于C组(P<0.05)。结论:盐酸戊乙奎醚可有效改善大鼠体外循环期间微循环,增加组织灌注。

Objective：To observe the effects of penehyclidine hydrochloride（PHC） on mice microcircula tion during extracorporeal circulation. Methods： 20 healthy SD rats were selected and randomly divided into two groups： control group and PHC group. PHC 0.05mg/kg were added to the priming solution of PHC group while C group added same volume of normal saline. Both control group and PHC group were processed extracorporeal circulation for two hours. The observation time was To ： before extracorporeal circulation; T1 ： 1 hour of extracorporeat circulation; T2：2 hours of extracorporeal circulation. The observation contains blood pressure, heart rate, differential of oxygen pressure between arterial and venous（Pa-vO2） ; Blood lactate ; urine volume for two hours of extracorporeal circulation. Results：Blood lactate was lower than that in PHC group in T2, Ta while Pa-vO2 was higher than than that in C group（P〈0.05） ; urine volume for two hours of extracorporeal circulation was higher than that in PHC group（P〈0.05） Conclusion： PHC can improve the tissue perfusion by ameliorating mice microcireulation during extracorporeal circulation.