文拉法辛与帕罗西汀治疗老年期抑郁症对照研究

Comparative study of Venlafaxine and paroxetine in treatment of patients with senile depression

目的比较文拉法辛与帕罗西汀治疗老年期抑郁症的临床治疗及安全性。方法将58例老年期抑郁症患者随机分为文拉法辛组与帕罗西汀组(各29例),疗程6周。用汉密尔顿抑郁量表(HAMD)评定疗效,用副反应量表(TESS)评定不良反应。结果文拉法辛组与帕罗西汀组的有效率分别为89.6%;和86.2%,两组相仿。但治疗1周及2周后,文拉法辛组的有效率高于帕罗西汀组。两组间不良反应比较差异无统计学意义。结论文拉法辛是一种起效快,且安全、有效的抗抑郁药物,能用于老年期抑郁症患者。

Objective To compare clinical effect and satety of Venlafaxine and paroxetine in the treatment of patients with senile depression.Methods Fifty-eight patients with senile depression divided into Venlafaxine group and paroxetine group respectirely for six weeks.The efficacy was assessed by Hamilton depression rating Scale（HAMD）and the safety was assessed by treatment emtrghte symtom scale（TESS）.Results The effective rate of Venlafaxine group and the paroxetine group were 89.6% and 86.2% respectively,which had no remarkable differences betweem two groups,The effective rate of citalopram group higher than that of paroxetine group after 1 and 2 weeks treatment.No obvious difference was found in adverse reactions between two groups.Conclusion Venlafaxine is a safe and effective drug in the treatment of geriatric depression.