癫癎患者认知功能障碍及其影响因素分析

Cognitive Dysfunction of Patients with Epilepsy and Its Influencing Factors

目的探讨癫癎患者认知功能障碍及其影响因素。方法采用韦氏儿童智力量表、成人智力量表对102例癫癎患者的认知功能进行评估,分析发病年龄、发作频率、发作时相、服用抗癫癎药物(AEDs)种类等因素对认知的影响。结果韦氏智力量表评估提示癫癎患者认知功能障碍发生率为82.2%。单因素差异分析显示发作频率、发作时相、单药治疗和多药治疗、服用AEDs种类均与认知功能损害程度相关。结论癫癎患者存在明显的认知功能障碍,发作频率、发作时相、AEDs服用情况均是影响癫癎患者认知功能的主要因素。

Aim To investigate epilepsy patients with cognitive dysfunction and its impact factors. Methods The cognitive function of 102 patients with epilepsy was assessed by children or adult Wechsler Intelligence Scale, and the influencing factors of cognition were analyzed, such as age of onset, seizure frequency, seizure phase, types ofantiepileptic drugs （AEDs）. Results According to the assessment of the Wechsler Intelligence Scale, the incidence of cognitive dysfunction with epilepsy patients was 82.2%. Single factor variance analysis showed that seizure frequency, seizure phase, single or multi-drug therapy, types of AEDs were associated with the degree of cognitive impairment. Conclusion Epilepsy patients have significant cognitive dysfunction. Seizure frequency, seizure phase, AEDs are the main factors impairing cognitive function.