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厄贝沙坦联合钙离子拮抗剂治疗老年2型糖尿病肾病合并高血压患者的疗效观察 被引量:33

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摘要 目的探讨厄贝沙坦和钙离子拮抗剂联合对老年人2型糖尿病肾病合并高血压患者的临床疗效。方法选择在综合病房住院的糖尿病肾病合并高血压患者60例,随机分为2组,A组用厄贝沙坦和络活喜治疗,B组用厄贝沙坦和硝苯地平缓释片治疗,对血压、尿微量白蛋白(u-ALB)、糖化血红蛋白(HbA1c)在治疗前后的变化情况进行比较。结果 2组治疗后,SBP、DBP均有所下降(P<0.01);u-ALB水平下降,且A组较B组下降更明显(P<0.05);2组HbA1c无明显变化(P>0.05)。结论厄贝沙坦联合钙离子拮抗剂治疗糖尿病肾病合并高血压疗效明确。
出处 《山东医药》 CAS 2012年第36期68-69,共2页 Shandong Medical Journal
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  • 1Velloso LA, Folli F, Sun X J, et al. Cross - talk between insulin and angiotensin signaling systems. Proc Nail Acad Sci USA, 1996, 93:12490 - 12495.
  • 2Teteuya Shiuchi, Tai - xing Cui, Lan Wu, et al. ACEI inhibitor improves insulin resistance in diabetic mouse via bradykinin and NO. Hypertension, 2002, 40: 329 - 334.
  • 3Nawano M, Anai M, Funaki M, et al. Imadapril, an angiotensin -converting enzyme inhibitor, improves insulin sensitivity by enhancing signal transduction via insulin receptor substrate proteins and improving vascular resistance in the Zucker fatty rat. Metabolism, 1999, 48:1248 - 1255.
  • 4Eros EG, Deddish PA, Marcic BM. Potentiating of bradykinin action by ACE inhibitiors. Trends Endocrinol Metab, 1999, 10:223 -229.
  • 5Henriksen EJ, Jacob S, Kinnick TR, et al. ACE inhibition and glucose transport in insulin resistant muscle: role of brandykinin and nitric oxide. Am J Physiol, 1999, 277:332 -336.
  • 6Leszek Kalinowski, Tomasz Matys, Ewa Chabielska, et al. Angiotensin Ⅱ AT1 receptor antagonists inhibit platelet adhesion and aggregation by nitric oxide release. Hypertension, 2002, 40:521 -527.
  • 7Haffner SM, Lehto S, Ronnenuna T, et al. Mortality from coronary heart disease in subjects with type 2 diabetes and in nondiabetic subjects with and without myocardial infarction. N Engl J Med, 1998, 339:229 - 234.
  • 8Patrick Henry, Fredefique Thomas, Athanase Benetos, et al. Impaired fasting glucose, blood pressure and cardiovascular disease. Hypertension, 2002, 40:458-463.
  • 9Grees TW, Nieto FJ, Shahar E, et al. Hypertension and antihypertensive therapy as risk factors for type 2 diabetes mellitus: Atheresclerosis risk in communities study. N Engl J Med, 2000, 342:905 -912.
  • 10Honsson L, Lindholm LH, Niskonen L, et al. Effect of ongiotensin -converting- enzyme inhibition compared with conventional therapy on cardiovascular morbidity and mortality in hypertension: the Captopril Prevention Project (CAPPP) randomized trial. Lancet, 1999, 353:611 -616.

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