ARTN、VEGF蛋白在胃癌组织中的表达及意义

Expression of ARTN and VEGF in gastric carcinom and its significance

目的探讨Artemin(ARTN)、血管内皮生长因子(VEGF)蛋白在胃癌组织中的表达和意义。方法采用免疫组化方法,检测60例胃癌患者的癌组织及48例胃癌患者的癌旁良性组织中ARTN、VEGF蛋白的表达,并分析二者与胃癌患者临床病理特征和预后的关系。结果 ARTN、VEGF蛋白在癌旁良性组织中的阳性表达率分别为14.6%、12.5%,在胃癌组织中的阳性表达率分别为78.3%、70.0%。胃癌组织中的ARTN、VEGF蛋白阳性表达率均明显高于癌旁良性组织(P均<0.01)。ARTN蛋白表达与胃癌患者的肿瘤浸润程度、TNM分期及淋巴结转移有密切关系(P均<0.05),且ARTN蛋白与VEGF蛋白表达呈正相关(r=0.131,P<0.01)。结论胃癌组织中的ARTN蛋白表达与肿瘤的侵袭转移有密切关系,与VEGF蛋白表达呈正相关,可作为临床评价胃癌进展和患者预后的指标之一。

Objective To investigate the expression of Artemin （ARTN） and VEGF in gastric carcinom and its sig- nificance. Methods The expressions of ARTN protein and VEGF protein were examined by S-P immunohistochmical method in 60 cases of gastric carcinom and 48 cases of paraneoplastic benign tissue. The relationships of ARTN and VEGF with clinicopathologic features and with progoosis were analysed. Results The postive rates of ARTN and VEGF proteins in paraneoplastic benign tissue were 14.6%, 12.5%, and in gastric carcinom were 78.3% ,70.0%. The postive rates of ARTN and VEGF proteins in gastric carcinom were both significantly higher than those in paraneoplastic benign tissue （P 〈 0.01 ）. The expression of ARTN was significantly correlated with the degree of infiltration, TNM staging and lymph node metastasis （P 〈 0.05 ）. The expressions of ARTN and VEGF proteins were positively correlated （r = 0.131, P 〈0.01）. Conclusions The expression of ARTN protein in gastric carcinoma significantly correlates with tumor invasion and metastasis, and positively correlates with the expression of VEGF protein, which could be used as one of the indicators of the clin- ical evaluation of gastric cancer progression and the prognosis of patients.