不同厂家小儿氨酚黄那敏颗粒剂及片剂分剂量的评价

Evaluation of Dose Splitting of Pediatric Paracetamol, Artificial Cow-bezoar and Chlorphenamine Maleate Granules and Tablets Manufactured by Different Pharmaceutical Factories

目的:评价不同厂家小儿氨酚黄那敏颗粒剂及片剂分剂量的合理性,为提高临床用药水平提供依据。方法:比较11个厂家的小儿氨酚黄那敏颗粒剂及3个厂家的片剂分剂量成半袋(半片)理论装量(重量)与实际装量(重量)有无显著性差异、不同操作者实际装量(重量)有无显著性差异及半袋实际装量(重量)准确性。结果:A厂的小儿氨酚黄那敏颗粒剂流动性最佳,分剂量成半袋后,半袋理论装量与半袋实际装量无显著性差异(P>0.05),不同人员操作半袋实际装量无显著性差异(P>0.05),且准确性良好。结论:A厂的小儿氨酚黄那敏颗粒剂适合分半服用。

Objective： To evaluate rationality of dose splitting of pediatric paracetamol, artificial cow-bezoar and chlorphenamine maleate （short for PACBC） granules and tablets manufactured by different pharmaceutical factories to provide reference for clinical use. Method： Compared theoretical weight with actual weight,actual weight split by two pharmacy-majored operators and the accuracy of actual weight of PACBC granules produced by 11 companies and tablets produced by 3 companies. Results： The flowahility of PACBC granules produced by company A is the best of all. When split into half package, there is no significant difference between theoretical weight and actual weight, with the best accuracy. Conclusion： PACBC granules produced by company A is suitable for splitting into half to use.