摘要
为了研究信号从激酶到达底物蛋白质后的传递机制,本文将磷酸化和蛋白质相互作用结合构建网络,利用复杂网络理论对该网络进行分析.结果发现,底物中存在的社区结构不会只传递特定激酶组的信号,影响网络稳定性的关键节点大多参与肿瘤发生相关的信号途径.
To explore the mechanism of downstream signaling from kinases to their substrates,a complex network method was developed by combining phosphorylation with protein-protein interactions.It shows that there are no independent community structures in this network and no single community served for signals from mere kinase group.On the other hand,key proteins of hub nodes showed great importance for the stability of whole network,and most of them were involved in pathways of tumor of cancer.
出处
《四川大学学报（自然科学版）》
CAS
CSCD
北大核心
2013年第2期359-365,共7页
Journal of Sichuan University(Natural Science Edition)
基金
国家自然科学基金(20905054
20972103)
关键词
磷酸化
蛋白质相互作用
复杂网络
社区结构
信号途径
phosphorylation
protein interaction
complex network
community structure
signaling pathway
