组织和器官脱细胞方法的研究进展

Progress of decellularized tissue and organ

用组织或器官脱细胞制成的生物支架已成功的应用于各种组织工程和再生医学。选用的组织不同,所用的脱细胞方法也不尽相同。细胞从组织中去除的效率取决于选择的脱细胞组织和所采用的脱细胞方法。每一种处理方法都会对支架的生物学组成、组织的超微结构、机械性能产生影响。本文对主要组织和器官常用的脱细胞方法进行描述,并考虑处理方法对生物支架材料的影响。

Decellularized tissue or organ scaffolds has been successfully used in tissue engineering and regenerative medicine. The selected tissue determined the used acellular methods. The efficiency of removal of cells from the tissue depends on the choice of tissue and selected the methods of decellularization. Each of these treatmentsaffect the biochemical composition, tissue ultrastructure, and mechanical behavior of the remaining extracellular matrix （ECM） scaffold. This paper described the research progress of main tissues and organs used in decellularization and consider the impact on the scaffold materials.