血清TK-1检测对原发性肝癌的诊断及介入治疗后效果评估的意义

Significance of serum thymidine kinase-1 for primary liver cancer detection and monitoring the response to transarterial chemoembolization

目的探讨血清TK-1检测对原发性肝癌诊断及介入治疗后效果评估的意义。方法应用免疫印迹-增强化学发光法检测28例健康人及54例原发性肝癌患者介入治疗前、治疗后1周及治疗1月后的血清TK-1水平,分别进行比较、分析。结果肝癌组与健康对照组之间血清TK-1水平差异有统计学意义(P<0.01)。介入治疗1月后TK-1水平显著下降(P<0.01)。介入治疗1月后血清TK-1水平<2pmol/L组的治疗效果明显好于>3pmol/L组,差异有统计学意义(P<0.01)。结论血清TK-1检测在原发性肝癌的辅助诊断、疗效监测等方面具有一定的临床应用价值。

Objective To evaluate the use of thymidine kinase-1（TK-1） in serum as proliferating tumor marker for primary liver cancer and monitoring marker for the response to transarterial chemoembolization（TACE）.Methods Serum levels of TK-1 expression were detected with sensitive chemiluminescence dot-blot assay in 28 healthy cases（control group） and 54 cases with primary liver cancer.The expressions of serum TK-1 were compared and analyzed 1 day before and 7 days,30 days after TACE.Results Compared with the control group,the concentration of TK-1 was significantly increased in patients with primary liver cancer（P0.01）,and the level of TK-1 was significantly dicreased 30 days after TACE（P0.01）.High serum TK-1 levels（3 pmol/L） 30 days after TACE predict poorer therapeutic effect（P0.01）.Conclusions In the patients with primary liver cancer,the level of TK-1 has value in the diagnosis and has the relationship with the therapeutic effect.