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慢性心功能不全患者生存素水平与心功能的相关性 被引量：6

The correlatoin between serum survivin and heart function in patients with chronic heart failure
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摘要 目的检测慢性心功能不全患者血清中生存素(survivin)水平,并与其临床及实验室指标等进行相关性分析,初步探讨慢性心功能不全患者血清survivin水平及其在心力衰竭发生发展中的作用。方法分析167例慢性心功能不全患者的临床资料,以临床心功能分级(NYHA分级)分为Ⅰ、Ⅱ、Ⅲ、Ⅳ级4组。采用双抗体夹心酶联免疫吸附测定法(ELISA)法检测其血清survivin水平。同时收集患者心胸比、B型脑钠肽(BNP)、左室射血分数(LVEF)等资料,对各组数据进行差异性比较和相关性分析。结果与心功能Ⅰ级组比较,心功能Ⅲ级组sur-vivin水平最高,心功能Ⅳ级survivin水平下降,与心功能Ⅲ级组比较差异有统计学意义(P<0.05);各组血清sur-vivin水平与心胸比、BNP呈正相关(r=0.71,r=0.55,P<0.05),与LVEF呈负相关(r=-0.78,P<0.05)。结论慢性心功能不全患者survivin表达增加,且与心脏功能的衰竭程度密切相关,在心功能Ⅲ级患者survivin表达水平最高,心功能Ⅳ级患者survivin水平下降,患者心力衰竭病情加重。 Objective To evaluate the correlation between serum survivin and heart function in patients with chronic heart failure （CHF）. Methods The BNP, serum survivin, cardiothoracic ratio and LVEF were assessed in 167 patients with chronic heart failure for analysis. Results Significantly higher survivin was revealed in patients with CHF （P 〈 0. 05 ）. Furthermore, significantly negative correlation was revealed between survivin and heart function （P 〈 0. 05 ）. Conclusion Elevated survivin is associated with heart function especially in patients with level m cardiac function （NYHA）, suggesting a risk factor of chronic heart failure.
作者 郭守玉 姜海 龙明智
机构地区 南京医科大学第二附属医院心血管内科
出处 《广东医学》 CAS CSCD 北大核心 2013年第6期861-863,共3页 Guangdong Medical Journal
基金 南京医科大学自然科学基金资助项目(编号:09njmum019)
关键词 慢性心功能不全 心脏功能 生存素 serum survivin chronic heart failure heart function
分类号 R541 [医药卫生—心血管疾病]
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参考文献18

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共引文献8

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二级引证文献18

广东医学
2013年 第6期

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