奥曲肽治疗急性水肿型胰腺炎72例临床研究

Clinical Research of Treatment of 72 Cases of Acute Edematous Pancreatitis by Octreotide

目的探讨奥曲肽治疗急性水肿型胰腺炎的治疗效果。方法回顾性分析2006年3月-2011年8月阜阳市第二人民医院72例急性水肿型胰腺炎患者的临床资料,两组患者年龄、性别、病因、发病时间、CT分级等比较差异无统计学意义。将其随机分为治疗组40例,对照组32例。应用统计学方法分析并比较两组患者治疗后血淀粉酶、C反应蛋白、腹痛缓解时间、恢复进食时间及住院时间等。结果治疗组38例治愈,有效率95%;对照组25例治愈,有效率78%,与对照组有明显区别(P<0.05);治疗后C反应蛋白、腹痛缓解时间、恢复进食时间及住院时间等治疗组均优于对照组(P<0.05);但血淀粉酶两组比较差异无统计学意义(P>0.05)。结论应用奥曲肽治疗急性水肿型胰腺炎较不用奥曲肽有更好的治疗效果,值得临床推广。

Objective To investigate the therapeutic effect of octreotide on acute edematous pancreatitis by. Methods The clinical data of 72 patients with acute edematous pancreatitis in our hospital from March 2006 to August 2011 were analyzed. There was no difference in age, gender, cause of disease, onset time, classification by CT, et al. All patients were randomly divided into treatment group（40 cases） and control group（32 cases）. The levels of serum amylase and C-reactive protein after the treatment, time in remission of abdominal pain and resuming taking foods,hospitalization time were statistically analyzed between the two groups. Results Thirty-eight patients in treatment group were cured with an effective rate of 95% ; twenty-five patients in control group were cured with an effective rate of 78% ,the difference was significant（P 〈 0.05 ）. After treatment,the evaluating indexes such C-reactive protein level, time in remission of abdominal pain, time in resuming taking foods and hospitalization time, but not serum amylase level, in the treatment group were better as compared to the control group（ P 〈 0.05 ）. Conclusion Octreotide has a better clinical effect on acute edema pancreatitis.