血浆D-二聚体水平与骨科创伤患者创伤程度的相关性研究

The Correlation between Plasma D-Dimer Levels and Traumatic Degree in Orthopedic Trauma Patients

目的检测骨创伤患者血浆D-二聚体水平的变化,探讨其与创伤程度的相关性。方法收集梧州市中医医院骨创伤患者84例,根据损伤严重程度(ISS)评分将84例骨创伤患者分为:轻度损伤组(ISS≤16)、中度损伤组(16<ISS<25)、重度损伤组(ISS≥25),另取30例健康体检者作为对照。D-二聚体使用免疫比浊法检测。结果入院后第1天,对照组和骨创伤组血浆D-二聚体的表达水平分别为(180.57±42.24)ng/ml和(1567.07±254.17)ng/ml,两组之间差异具有统计学意义(P<0.01)。骨创伤患者D-二聚体的表达水平在轻度损伤组、中度损伤组和重度损伤组分别为(721.16±144.24)ng/ml、(1506.37±267.21)ng/ml和(2041.55±346.82)ng/ml,各组之间差异存在统计学意义(P<0.05)。骨创伤患者在第1,3,7天血浆中D-二聚体的表达水平分别为(1567.07±254.17)ng/ml、(1024.15±193.26)ng/ml和(642.58±138.22)ng/ml,各组之间差异存在统计学意义(P<0.05)。结论骨创伤患者血浆中D-二聚体表达升高,D-二聚体水平的检测可用于患者伤情的判断、预后的评估。

Objective To investigate the correlation between plasma D-dimer levels and traumatic degree in orthopedic trauma patients. Methods A total of 84 orthopedic trauma patients were enrolled in this study. According to the ISS scores, the 84 cases were devided into mild trauma group （ISS ≤ 16）, moderate trauma group （16 〈 ISS 〈 25 ）, and severe trauma group （ISS I〉 25）. Another 30 healthy person were usded as a normal control. The levels of plasma D-dimer was measured with turbidimetric immunoassay. Results After in hospital for 1 day, the levels of plasma D-dimer in normal control and orthopedic trauma group was 180.57 ±42.24 and 1567.07 ± 254. 17 ng/ml, respectively. There was significant difference between the two groups（ P 〈 0.01 ）. The plasma levels of D-dimer in mild,moderate ,and severe trauma group was 721.16 ±144.24,1506.37 ± 267.21 and 2041.55 ± 346.82 ng/ml, respectively. There was significant difference among the three groups （P 〈 0.05 ）. After in hospital for 1,3 ,and 7 days,the plasma levels of D-dimer was decreased from 1567.07 ±254.17 to 1024.15 ± 193.26 and 642.58 ± 138.22 ng/ml （ P 〈 0.05 ）. Conclusion The high-level expression of plasma D-dimer was found in orthopedic trauma patients, and which could be used to predict the extent of trauma and assess the progression of trauma.