甲基苯丙胺戒断者记忆障碍的毒品相关n-back任务

THE DRUG-RELATED N-BACK TASK OF MEMORY IMPAIRMENT IN METHAMPHETAMINE ABSTINENTS

目的:利用毒品相关n-back任务测量甲基苯丙胺戒断者是否存在记忆障碍。方法:利用NuAmps 40导事件相关电位系统,记录并比较甲基苯丙胺戒断者(研究组)与健康志愿者(对照组)(各12例)对3类汉字(包括毒品主要相关词、毒品次要相关词、无关词)的反应。结果:正常对照组的P300波幅随着记忆负荷逐步增加而逐渐下降(1-back>2-back),而甲基苯丙胺戒断组没有显著性差异。正常对照组与甲基苯丙胺戒断组P300峰值有显著性差异。在顶区(PZ电极)P300峰值有显著性的组间差异。结论:甲基苯丙胺戒断者存在记忆功能障碍,毒品相关n-back任务可成为检测甲基苯丙胺戒断者记忆功能障碍较好的工具之一。

Objective： To investigate whether methamphetamine abstinents have memory impairment with the drug - related n - back task. Methods ： NuAmps 40 event - related potential system was used to record and compare the reaction in abstinent and normal groups （12 cases in each group） for the three types of items including the main drug related words, secondary drug related words and unrelated ones. Results：The amplitude of P300 in normal group decreased with memory load gradually increasing （ 1 - back 〉 2 - back）, while no significant difference in methamphetamine abstitents group.The P300＇ s peak values in normal group and methamphetamine abstinents group were significantly different. In the parietal area （ PZ electrode） P300＇ s peak values were significantly different between the two groups. Conclusion： Methamphetamine abstinents have memory impairment, and drug -related n - back task can be a good method to test memory impairment in methamphetamine abstinents.