中药三联疗法对急性脑梗死疗效及对脑血流量的影响

Clinical Effect of Triple Therapy of Chinese Medicine for Acute Cerebral Infarction and its Influence on Cerebral Blood Flow

目的:研究中药三联疗法对急性脑梗死治疗效果及对脑血流量的影响。方法:286例急性脑梗死患者随机均分为观察组与对照组,各143例,观察组予以中药三联疗法治疗,包括自拟中风方煎服,1剂/d;直肠滴注中风方500 mL,1剂/d;银杏叶注射液10 mL,静脉滴注,1次/d。对照组以静脉滴注银杏叶注射液10 mL,1次/d;胞磷胆碱0.5 g,静滴,1次/d。两组疗程均为14 d。比较两组的治疗效果及脑血流量变化。结果:观察组总有效率88.8%(127/143),对照组74.1%(106/143),观察组高于对照组(P<0.05)。观察组患者治疗前后脑血流量为(583.1±114.2),(663.5±99.3)mL·min-1,对照组患者治疗前后为(594.1±105.9),(615.47±96.5)mL·min-1,治疗后观察组明显高于对照组(P<0.05)。结论:中药三联疗法治疗急性脑梗死,能够改善脑供血,促进神经功能恢复,值得临床进一步推广实践。

Objective：To investigate the effect of triple therapy of Chinese medicine for acute cerebral infarction and its influence on cerebral blood flow.Method：Two hundred and eighty-six patients with acute cerebral infarction were randomly divided into two groups.The observation group was accepted triple therapy of Chinese medicine,including Zhongfeng Fang 1 dose daily;Zhichang Dizhu Zhongfeng Fang 1 dose daily and ginkgo leaf injection 10 mL daily.The control group was treated with ginkgo leaf injection 10 mL daily,citicoline 0.5 g iv daily.All treatment lasted for 14 days.Recovery of neurological function and the changes of cerebral blood flow were evaluated and analyzed.Result：Compared with the control group,the total efficiency of the observation group was significantly higher（88.8% vs.74.1%,P0.05）.The mean cerebral blood flow comparison of two groups after therapy showed statistically difference [（663.5±99.3） mL·min-1 vs（615.47±96.5） mL·min-1,P0.05].Conclusion：Triple therapy of Chinese medicine for acute cerebral infarction results in better cerebral blood flow recovery,and helps to improve the recovery of neurological function,which worthy of further clinical application.