艾迪注射液对肺癌放疗患者细胞因子表达的影响

Effect of Aidi Injecttion on the Cytokine Expression of Radiotherapy for Lung Cancer

目的:探讨艾迪注射液对肺癌放疗患者血清细胞因子的影响。方法:将40例肺癌患者,随机分为治疗组(20例)和对照组(20例),两组均予三维适行放疗(3DCRT),治疗组在此基础上加用艾迪注射液。比较放疗前后两组患者血清中白细胞介素-6(IL-6),肿瘤坏死因子-α(TNF-α)和转化生长因-β(TGF-β)水平的变化及放射性肺炎(RP)发生率的差异。结果:治疗组在放疗结束后细胞因子IL-6,TNF-α和TGF-β的水平明显低于对照组,二者比较差异有显著性(P<0.05);两组RP的发生率相近。结论:艾迪注射液能降低肺癌放疗患者血清细胞因子IL-6,TNF-α和TGF-β的水平,延缓放射性肺炎的进展,有效预防放射性肺炎的发生。

Objective：It is to explore the effect of Aidi Injecttion on the expression of radiotherapy for lung cancer patients.Method：Fourty cases of lung cancer were randomly divided into treatment group（20 cases） and control group（20 cases）.The two groups were given three-dimensional conformal radiation therapy（3D CRT）.Meanwhile,the treatment group was added Aidi injecttio.There were some indices compared before and after radiotherapy including the serum interleukin-6（IL-6）,the tumor necrosis factor-α（TNF-α） and the transforming growth factor-β（TGF-β）.And then,the incidence of the radiation pneumonia were also compared between two groups.Result：After the end of treatment,the IL-6,the TNF-α and the TGF-β of the treatment group were lower than those of the control group.There was significant difference（P0.05）.Nevertheless there were no significat differences between two groups about incidence of the radiation pneumonitis.Conclusion：Aidi injecttion could relieve the progress of Radiation pneumonitis through decreasing levels of the IL-6,the TNF-α and the TGF-β,thus,prevention of the occurrence of radiation pneumonia.