傅立叶OCT对不同年龄正常人群角膜厚度的测量研究

Corneal thickness measurements obtained with Fourier-domain optical coherence tomography in different age groups of healthy subjects

目的:研究傅立叶域光学相干断层成像系统(Fourier-domain optical coherence tomography,FD-OCT)测量不同年龄人群角膜厚度正常值。方法:选取健康受试者210例420眼,分为3组,青年组(18～40岁)70例140眼;中年组(41～60岁)70例140眼;老年组(≥61岁)70例140眼。用傅立叶OCT检测受试者双眼角膜中心区、内环区和外环区角膜厚度及平均角膜厚度。结果:通过FD-OCT测量的不同区域角膜厚度最薄处位于角膜中心区,平均厚度527.19±1.72μm;最厚处在外环上方,平均厚度582.42±2.50μm;左右眼不同区域间角膜厚度差异没有统计学意义(P>0.05)。通过FD-OCT测量的平均角膜厚度在三个不同年龄组间具有很好的一致性及相关性(右眼:青年组-中年组:r=0.949,中年组-老年组:r=0.924,青年组-老年组:r=0.981;左眼:青年组-中年组:r=0.996,中年组-老年组:r=0.901,青年组-老年组:r=0.876)。结论:采用FD-OCT前节功能测量角膜厚度具有可重复性、可信性、方便性,可以更好地代表实际上的角膜厚度。

AIM： To study normal value of corneal thickness in healthy subjects in different age groups with Fourier- domain optical coherence tomography （FD-OCT）. METHODS：Total 420 eyes of 210 healthy volunteers were analyzed. These were divided into three groups： young group （YG, n=70, 140 eyes, 18 to 40 years old）, medium group（MG, n= 70, 140 eyes, 41 to 60 years old）, old group（OG, n=70, 140 eyes, more 61 years old）. Corneal thickness in central zone and inner-ring and outer-ring zones were measured by using FD-OCT. RESULTS： The thinnest zone was 527. 19 ± 1. 72μm in central cornea zone, and the thickest zone was 582.42±2. 501μm in superior in outer zone. Differences of corneal thickness were not significant in different measured zones （P〉0.05）. Average values of corneal thickness made by FD-OCT was better consistent and highly correlated for three groups （right eye： YG-MG： r=0.949, MG-OG： r= 0.924,YG-OG： r=0.981, left eye： YG-MG： r=0.996, MG-OG： r=0.901, YG-OG： r=0.876）. CONCLUSION： Measurement of cornea thickness by FD-OCT is more reproducible, reliable and convenient, and may better represent actual cornea thickness.