OCT在急性中心性浆液性脉络膜视网膜病变诊治中的应用

Application of OCT in treatment of acute central serous chorioretinopathy

目的:应用OCT动态观察急性中心性浆液性脉络膜视网膜病变(acute central serous chorioretinopathy,ACSC)细微结构的变化,比较其激光治疗、药物治疗与二者联合治疗的疗效。方法:经FFA及OCT确诊的96例98眼ACSC患者,应用OCT比较单纯药物治疗、激光治疗以及激光联合药物治疗对视网膜下液的吸收,并比较各组间的视力差异。随访时间为治疗后2,4,8wk。结果:各组之间在治疗前视网膜脱离范围均没有统计学意义。在治疗后2,4,8wk比较,激光治疗组与药物治疗组间视网膜脱离范围和治愈率均没有统计学意义;联合治疗组与前两组比较,其视网膜脱离范围更小,治愈率更高,其差异均有统计学意义。结论:药物联合激光治疗急性中心性浆液性脉络膜视网膜病变能缩短病程,提高治愈率;OCT无创、简便、直观,能对CSC的愈后过程进行灵敏的追踪。

AIM： To dynamically observe the subtle structure changes in the acute central serous chorioretinopathy （ACSC） by optical coherence tomography （OCT）. Compare the efficacy of laser, drug and the combined treatment. METHODS： Totally 96 cases （98 eyes） of ACSC were confirmed by FFA and OCT, the differences of subretinal fluid absorption and visual acuity by drug, laser and laser combined with drug therapy were compared. Follow-up time was 2 weeks, 4 weeks and 8 weeks. RESULTS： Between the groups were no statistically significant in the range of retinal detachment before treatment. After 2, 4 and 8 weeks treatment, the range of retinal detachment and cure rates were not statistically significant between the laser group and drug group. Compared to aforementioned two groups, a smaller range of retinal detachment and higher cure rate was found in combined treatment group, the differences were statistically significant. CONCLUSION： The combined treatment of drug and laser can shorten the course of ACSC, improve the cure rate; OCT is noninvasive, simple, intuitive, can sensitively track the healing process of ACSC.