应用增强深度成像技术测量CSC黄斑区脉络膜厚度的研究

Choroid thickness in central serous chorioretinopathy using enhanced depth imaging optical coherence tomography

目的:观察中心性浆液性脉络膜视网膜病变(central serous chorioretinopathy,CSC)患眼和对侧健眼黄斑区脉络膜厚度,并与正常人群比较,分析其临床意义。方法:选择2011-09/2012-09共26例26眼门诊就诊的单眼发病的CSC患者,分为CSC患眼组(A组)26眼,CSC对侧健眼组(B组)26眼,正常对照组(C组)26眼。采用海德堡频域OCT增强深度成像技术测量中心凹下脉络膜厚度、距中心凹1和3mm处鼻颞上下四方位脉络膜厚度。结果:配对t检验显示CSC患眼SFCT值较对侧健眼明显增厚(t=5.57,P<0.01)。三组间比较,SFCT均值分别为(528.31±91.24)μm,(413.71±79.35)μm和(301.31±52.46)μm,A组较B组增厚,A组较C组明显增厚,B组较C组增厚,差异均有统计学意义。结论:CSC患眼黄斑区脉络膜厚度较对侧健眼及正常对照组明显增厚,提示脉络膜血管呈高灌注状态,可能是CSC发病的因素之一。

AIM ： To observe the choroidal thickness in the macular area in affected and unaffected fellow eyes with central serous chorio retinopathy （CSC） and in healthy controls. METHODS： Twenty-six cases with unilateral CSC and controls were recruited in this study. All eyes were divided into three groups： 26 eyes in Group A（affected eyes with CSC）, 26 eyes in group B （unaffected fellow eyes） and 26 eyes in group C（right eyes of age and sex matched control）. Enhanced depth imaging was obtained by using spectral-domain optical coherence tomography. Subfoveal choroidal thickness and choroidal thickness at lmm/3mm nasal, temporal, superior and inferior to the fovea were measured. RESULTS： Choroidal thickness was significantly increased in affected eyes with CSC than unaffected fellow eyes （t= 5.57, P〈0.01 ）. The mean subfoveal choroidal thickness（SFCT） was 528.31± 91. 24μ m in group A, 413.71 ± 79.35μm in group B, and 301.31±52.46 in group C. The subfoveal choroid was significantly thicker in group A than Group C（ P〈0.01 ）. SFCT in unaffected fellow eyes were thicker than the controls（ P〈0.01 ）. CONCLUSlON：Choroidal thickness is thicker in affected eyes with CSC and also indicating that the choroid perfusion state, may be disease CSC. in fellow unaffected eyes, blood vessels are high and one of the factors of the disease CSC.