NAION患者外周血T淋巴细胞亚群和NK细胞变化

The peripheral blood T-lymphocyte subsets and natural kill cell in patients with nonarteritic anterior ischemic optic neuropathy

目的:研究非动脉炎性前部缺血性视神经病变(nonarteritic anterior ischemic opticneuropathy,NAION)患者外周血T淋巴细胞亚群的变化。方法:采用流式细胞仪单克隆免疫荧光法,观察30例NAION患者CD3+,CD4+,CD8+,CD4+"CD8+和NK的变化,并与正常对照组比较。结果:NAION组CD3+和CD4+"CD8+值无统计学差异(P>0.05),CD4+和CD8+减少,NK明显增加。结论:NAION患者T淋巴细胞亚群功能紊乱。

AIM： To study the peripheral blood T-lymphocyte and natural kill （NK） cell in patients with nonarteritic anterior ischemic optic neuropathy（NAION）. METHODS： The changes of CD3＋, CD4＋, CD8＋, CD4＋/CD8＋, NK in 30 NAION and 31 normal controls were measured by flow cytometry monoclonal immunofluorescence. RESULTS. CD3＋, CD4/CD8 ratio in NAION patients had no significant difference from normal control, CD4, CD8＋ decreased significantly. CONCLUSION. Serious immunological disturbances of T lymphocyte subsets exist in NAION patients.