新疆地区乳腺癌与人乳头瘤病毒感染相关性研究

Relationship between breast cancer and HPV infection in Xinjiang

目的探讨新疆地区人乳头状瘤病毒(human papillomavirus,HPV)感染与乳腺癌临床组织病理间的关系。方法 325例乳腺癌患者癌组织(乳腺癌组)和65例乳腺腺病患者乳腺组织(对照组),2组提取DNA,采用基因芯片技术检测乳腺癌中HPV DNA并进行分型,分析HPV感染与乳腺癌组织病理间的关系。结果乳腺癌组HPV阳性率11.7%,对照组9.2%,差异无统计学意义(P>0.05);乳腺癌组主要为HPV16感染,对照组主要为HPV11感染;乳腺癌组HPV感染在导管癌分化程度上差异有统计学意义(P<0.05),在肿瘤大小、肿瘤类型、淋巴结转移情况、雌激素受体、孕激素受体、人类表皮生长因子受体2表达情况及临床分期上差异无统计学意义(P>0.05)。结论 HPV感染与新疆地区乳腺癌的发生、发展不存在相关性。

Objective To investigate the relationship between human papillomavirus （ HPV ） infection and clinicopathological changes of breast cancer in Xinjiang. Methods HPV genotypes were detected by gene chip in 325 cases of breast cancer tissue and 65 cases of breast adenosis tissue to analyze the relationship between HPV infection and breast cancer clinicopathological changes. Results The positive rate of HPV infection was 11.7~/oo and 9.2~ in breast cancer group and breast adenosis group, which showed no significant difference between two groups （P^O. 05）. HPV16 infection was the most common type in breast cancer group, and HPV11 infection was the most common type in breast adenosis group. There was a signigicant difference in the differentiation grades of ductal carcinoma （P〈0.05）, and there were no significant differences in tumor size, cancer type, lymph node metastasis, estrogen receptor, progesterone receptor, the expression of epidermal growth factor receptor 2 and clinical stage （P〉0.05）. Conclusion HPV infection is not correlated with the occurance and development of breast cancer in Xinjiang.