血清间皮素检测上皮性卵巢癌临床价值

Clinical value of mesothelin to the diagnosis of epithelial ovarian carcinoma

目的探讨血清间皮素在上皮性卵巢癌鉴别诊断中的临床价值。方法卵巢癌患者100例(卵巢癌组)、卵巢炎症患者50例(卵巢炎症组)与体检健康者150例(对照组),采用ELISA法检测3组血清间皮素水平,采用电化学发光法检测血清糖类抗原125(carbohydrale antigen 125,CA125)水平,评价血清间皮素与CA125诊断卵巢癌的效能。结果卵巢癌组血清间皮素和CA125水平明显高于卵巢炎症组和对照组(P<0.05),卵巢炎症组血清CA125水平高于对照组(P<0.05),血清间皮素水平与对照组比较差异无统计学意义(P>0.05);卵巢癌组Ⅰ期患者血清间皮素和CA125水平与Ⅱ～Ⅳ期患者比较差异有统计学意义(P<0.05);血清间皮素诊断卵巢癌的敏感度为89.00%,特异性为84.50%,CA125的敏感度为87.00%,特异性为85.50%,二者联合检测的敏感度为98.00%,特异性为95.50%。结论血清间皮素诊断上皮性卵巢癌具有较高敏感度和特异性,与CA125联合检测具有较高临床应用价值。

Objective To explore the clinical value of mesothelin level to the differential diagnosis of ovarian carcinoma. Methods ELISA technique was applied to detect the serum mesothelin level in 100 patients with ovarian cancer （cancer group）, 50 patients with ovarian inflammation patients （inflammation group） and 150 healthy subjects （control group）. Electrochemiluminescence immunoassay was applied to detect the serum carbohydrate antigen 125 （CA125） level. Meanwhile, the diagnostic efficiency for ovarian carcinoma was also evaluated. Results The levels of mesothelin and CA125 were higher in cancer group than those in inflammation group and control group （P〈0.05）. The CA125 level was higher in inflammation group than those in control group （P〈0.05）, and there was no significant difference in mesothelin level between inflammation group and control group （P〉 0.05）. There were significant differences in the levels of mesothelin and CA125 between stages Ⅰ and stage Ⅱ to Ⅳ in cancer group （P〈0.05）. The sensitivity was 89.00% and 87.00%, and the specificity was 84.50% and 85.50% of mesothelin and CA125 respectively. The sensitivity and the specificity of joint detection were 98. 00% and 95. 50%, respectively. Conclusion Serum mesothelin has higher sensitivity and specificity, and the joint detection with CA125 has high clinical value to the diagnosis of ovarian cancer.