RUNX3蛋白表达与胃癌风险相关性的Meta分析

Correlation between RUNX3 Expression and Gastric Cancer Risks: A Meta-Analysis

目的系统评价RUNX3蛋白表达与胃癌及其不同临床病理特征的相关性。方法计算机检索PubMed、EMbase、VIP、WanFang Data和CBM,查找国内外公开发表关于RUNX3蛋白表达与胃癌及其不同临床病理特征相关性的病例-对照研究,检索时限均为从建库至2013年2月28日,同时追溯纳入文献的参考文献。由2位研究者根据纳入与排除标准独立筛选文献、提取资料和评价质量后,采用RevMan 5.0软件进行Meta分析。结果最终共纳入6个病例-对照研究,其中胃癌组405例,正常胃黏膜组185例。Meta分析结果显示:胃癌组的RUNX3表达低于正常胃黏膜组,两组差异有统计学意义[OR=0.07,95%CI(0.04,0.12),P<0.000 01];胃癌伴淋巴结转移组的RUNX3表达低于胃癌无淋巴结转移组,两组差异有统计学意义[OR=0.37,95%CI(0.23,0.61),P<0.000 1];胃癌浆膜以内浸润组的RUNX3高于胃癌浆膜及其外浸润组,两组差异有统计学意义[OR=3.92,95%CI(2.29,6.71),P<0.000 01];胃癌高分化组的RUNX3表达高于胃癌中低分化组,两组差异有统计学意义[OR=0.36,95%CI(0.22,0.58),P<0.000 1]。结论 RUNX3蛋白的表达与胃癌及其不同临床病理特征有显著相关性。受纳入研究数量和质量限制,上述结论尚待开展更多高质量研究加以验证。

Objective To investigate the correlation between RUNX3 expression and human gastric cancer, as well as its clinically pathologic features. Methods Such databases as PubMed, EMbase, VIP, WanFang Data and CBM were searched from their inception to February 28th, 2013 to collect case-control studies about the correlation between RUNX3 expression and human gastric cancer, as well as its clinically pathologic features, and the relevant references of the included literature were also retrieved. Two reviewers independently screened the literature according to the inclusion and exclusion criteria, extracted the data, and assessed the methodological quality. Then meta-analysis was conducted us- ing RevMan 5.0 software. Results A total of 6 case-control studies were included, which included 405 cases in the gastric cancer group and 185 cases in the normal gastric mucosa group. The results of meta-analysis showed that, RUNX3 expres~ sion was lower in the gastric cancer group than the normal gastric mucosa group, with a significant difference （OR=0.07, 95%CI 0.04 to 0.12, P〈0.000 01）; it was also lower in the subgroup of gastric cancer accompanied with lymph node me- tastasis than that without lymph node metastasis （OR=0.37, 95%CI 0.23 to 0.61, P〈0.000 1）; but it was higher in the sub- group of gastric cancer that had infiltrated into serosa than that had not, with a significant difference （OR--3.92, 95%CI 2.29 to 6.71, P〈0.000 01）; and it was also higher in the subgroup of well differentiated gastric cancer that the moderately and poorly differentiated, with a significant difference （OR=0.36, 95%CI 0.22 to 0.58, P〈0.000 1）. Conclusion RUNX3 expression is notably correlated to gastric cancer and its clinically pathologic features. For the quantity and quality limita- tion of the included studies, this conclusion still needs to be further proved by performing more high quality studies.