肝硬化“虚损生积”论——刘平教授学术思想浅析

Theory of "Asthenia and Deficiency Cause Accumulation" in Liver Cirrhosis——Brief Analysis on Academic System of Professor Liu Ping

刘平教授通过对大量中医文献的整理分析,并结合现代肝硬化的临床与基础研究,提出了"血瘀为积之标,虚损乃积之本"的肝硬化"虚损生积"中医病机理论。其中"虚损"主要表现在肝脾气虚和肝肾阴精虚损两个方面,气虚反映了机体功能的损伤与降低,而肝肾阴精虚损则指肝脏形质损伤,是虚损更深层次的病机变化。通过基础研究进一步明确"虚损"主要体现在肝实质细胞数量的减少与功能的衰退以及肝窦壁的损伤;而"血瘀"主要表现为肝脏细胞外基质的过度沉积。对阴精虚损的救治只能缓图,而"气虚"当先急顾,可冀"气中生精"。

On the basis of literature analysis and combination of clinic and theory,Professor Liu put forward that ＂asthenia and deficiency cause accumulation＂,which is the pathogenesis of liver cirrhosis.＂Asthenia and deficiency＂ is mainly manifested in liver-spleen qi deficiency and liver-kidney yin deficiency.The qi deficiency shows the damage and reduction of body function,and liver-kidney yin deficiency shows the physical damage of liver,which is the further pathogenesis.He views that ＂asthenia and deficiency＂ mainly manifests the reduction of liver parenchyma cells,dysfunction of liver parenchyma cells and damage of liver sinusoid wall;and ＂blood stasis＂ mainly manifests the excessive deposition of liver extracellular matrixc.Deficiency of yin-essence should be treated gradually,but ＂qi deficiency＂ should be treated emergency.