β-环糊精包合通管颗粒挥发油工艺优化研究

On β-cyclodextrin Inclusion Technology of Volatile Oil from "Tongguan Granule"

目的:研究β-环糊精包合通管颗粒中混合挥发油的最佳工艺。方法:采用饱和水溶液法制备包合物,通过正交试验设计对包合工艺条件进行优选,并采用薄层色谱法对包合物进行验证。结果:最佳挥发油包合工艺条件为:挥发油∶β-环糊精∶水(1∶8∶80),包合温度50℃,搅拌时间120 min。结论:优选的包合工艺操作简便、工艺稳定、挥发油包合率和包合物得率高。

Objective： To obtain the optimum inclusion technology of volatile oil from ＂Tongguan Granule＂ with β-cyclodextrin（β-CD）.Methods： The inclusion compounds was prepared by saturated peroxide solution method and characterized by thin layer chromatography（TLC）.Orthogonal design was applied to optimize preparation conditions.Results： The optimum conditions for inclusion process were as follows： the ratio of volatile oil（ml） to β-CD（g） was 1 ∶8;the ratio of amount of water to β-CD was 80 ∶1;the inclusion temperature was 50 ℃and clathrationtime was 120 min.Conclusion： This inclusion process is simple,stable and reliable,and of a high inclusion rate and a high yield of inclusion compound.