甲硫氨酸维B_1在肝内胆汁淤积症中的疗效

目的甲硫氨酸维B1注射液治疗肝内胆汁淤积症的疗效。方法将150例肝内胆汁淤积症患者随机分观察组和对照组,在予甘草酸二胺和维生素C等基础治疗的同时,观察组分别予甲硫氨酸维B1注射液,对照组给予门冬氨酸钾镁注射液,疗程为4周的退黄治疗。观察两组治疗效果.结果观察组有效率为91.3%,对照组有效率为78.6%,2组有效率比较差异有统计学意义(P<O.05)。甲硫氨酸维B1注射液治疗肝内胆汁淤积症,治疗4周,肝功能指标基本恢复正常,总胆红素、碱性磷酸酶下降大于50%。与对照组比较(P<0.01),差异有统计学意义。结论甲硫氨酸维B1注射液治疗肝内胆汁淤积症,较门冬氨酸钾镁注射液使患者肝功能指标恢复方面效果明显,值得临床推广。

Objective To observe the curative effect of methionined B1 injection treatment of intrahepatic cholestasis. Methods 150 cases of intrahepatic cholestasis disorder were randomLy divided into two groups, based on the glycyrrhizic acid diamine and vitamin C and other basic treatment, observation group were given the methionined B 1 injection, control group were given nmda potassium magnesium injection for treatment of four weeks. Results The effective rate of observation group was 91.3%, effective rate of control group was 78.6%, there was significant difference between the two groups （P〈0.05）. Methionined B 1 injection treatment of intrahepatic cholestasis,treatment of 4 weeks, liver function index basic returned to normal, total bilirubin and alkaline phosphatase down more than 50%. Compared with controls （P〈0.01）, difference have statistical significance. Conclusion Methionined B 1 injection has obvious effects on liver function index recovery ,which is superior than nmda potassium magnesium injection, it is worth clinical promotion.