依托考昔片联合甲钴胺注射液治疗腰椎间盘突出症疗效观察

Clinical efficacy of combination of etoricoxib tablets and mecobalamin injection in treatment of patients with prolapse of lumbar intervertebral disc

目的探讨依托考昔片联合甲钴胺注射液治疗腰椎间盘突出症的临床有效性和安全性。方法选择2010年1月至2012年8月收治的146例腰椎间盘突出症患者的临床资料,其中对照组76例患者采用布洛芬缓释胶囊进行治疗,而对照组70例患者采用依托考昔片联合甲钴胺注射液进行治疗,比较两组患者的临床效果。结果治疗后,观察组患者的视觉模拟评分法(VAS评分)以及Oswestry功能障碍指数(ODI)评价的改善情况均明显优于对照组(P<0.05),且两组患者不良反应的发生率基本相当,差异无统计学意义(P>0.05)。结论依托考昔片联合甲钴胺注射液治疗腰椎间盘突出症患者具有十分显著的疗效,值得临床推广。

Objective To explore the clinical efficacy and safety of the combination of etoricoxib tablets and mecobalamin injection m treatment of patients with prolapse of lumbar intervertebral disc. Methods One hundred and forty six patients with prolapse of lumbar interver- tebral disc were divided into two groups ： 76 patients in control group were treated with ibuprofen sustained - release capsules and 70 patients in observation group were treated with the combination of etoricoxib tablets and mecobalamin injection. The clinical effect of these two groups was compared. Results After treatment, the improvement of VAS and ODI scores in observation group was significantly better than those of control group （ P 〈 0.05 ）. The incidence of adverse reactions in these two groups was similar, and their difference was not statistically significant （ P 〉 0.05 ）. Conclusion The combination of etoricoxib tablets and mecobalamin injection in treatment of patients with prolapse of lumbar intervertebral disc has very significant effect, and it is worthy for promotion.